A New Study out of Aalto University
In conjunction with researchers from Helsinki University Hospital and Harvard Medical School , a study has shown a surprising connection that excites us here at RCDOM.
Their study consisted of 12 people with CRPS and 8 people with another form of chronic pain. Upon comparing their MRI’s, there was a strong similarity in all 12 CRPS patients that the other 8 lacked:
A 21% Volume Difference in the size of their Choroid Plexus.
For those that don’t know what your choroid plexus is: it is one of the major producers of fluid in your spinal cord and around your brain. This fluid protects and cushions the central nervous system and source for maintenance of the brain. It also is a point of entry for immune cells to enter the brain, so essentially it is a nervous system cosway.
In the past we have reported about glial cells. These cells are very important in the creation and maintenance of pathological pain state. If we can find out why glial cells are malfunctioning and why these researchers have found the choroid plexus is enlarged in patients with CRPS, we may find the cause and maybe even a solution to this pain that we are feeling.
This study is definitive proof that there is a connection between brain inflammation and chronic pain, such as CRPS. It also confirms suspicions that CRPS has connection to another well known autoimmune disease, multiple sclerosis. Multiple Sclerosis has been also found to be linked to a malfunctioning choroid plexus.
This new provides a large amount of hope to a community that needs it. I hope this opens many new doors for researchers to explore.
Enlargement of choroid plexus in complex regional pain syndrome: http://www.nature.com/articles/srep14329
Additional studies of Interest:
MAURY M. BREECHER Glial Cells and Pain Control
50th Annual Meeting of the American Headache Society Boston, Massachusetts June 26-29, 2008